Two-Piece Hard Capsules Liquid Filling and Band Sealing Line
The LiCaps 20 Two-Piece Hard Capsules Liquid Filling and Band Sealing Line is adopt with Germany liquid pump ,Japan yaskawa servo feeding system and the closed turntable design which can ensure the measuring precision within ±1.5%. The machine can fill oily liquid, liquid, suspension liquid or paste etc. This high-precision, cGMP compliant, development-scale machine automatically fills and seals two-piece capsules with liquid or semi-solid formulations
The CapSeal 20 Hard capsule sealing machine has realized improvement in stability of drug products by preventing leak from the capsule filled with oily drug, preventing oxidation of the drug, and having deodorization effect. Hence, it enables high precision sealing of hard capsules, allowing manufacturing of drugs with excellent physical stability.
- Up to 20,000capsules/hour
- Liquid filling and sealing with one automatic machine
- Siemens PLC and touch screen control
- Handles both oil or paste substance
- Designed for ease of use and high reliability, with the ability to quickly clean and change capsule sizes with optional parts
- Enclosed main turn table avoid dust getting into mechanical parts.
- Product integrity ensured with gentle handling of capsules before sealing and during the drying cycle
- Advanced Germany liquid pump
- Efficient capsule separation by means of vacuum.
- Safety interlocked guarding
- Alarm for door open
- Alarm for lower level of capsule
- cGMP compliant
- CE Marked
|Technical Data||In-Line LiCaps 20+CapSeal 20|
|Oil Filling Head||6|
|Application range||Capsule sizes: #00,#0, #1, #2, #3|
Each size requires a set of capsule tooling.
|Max. output||20,000 capsules/h|
(actual speed depends on formulation characteristics, filled volumn, capsule size .. etc)
|The filling accuracy||±1.5%|
|Power source||380V , 3 phase 5 wire , 50 HZ|
|Machine dimensions||3800(L) x900(W) x1700(H) mm|
|Machine Weight||2300 Kg ( approx )|
Liquid Capsule Filling Machine: The Ultimate FAQ Guide
This guide will answer all questions you have been asking about the liquid capsule filling machine.
Among the key things you will learn here include parts, working principle, benefits, material type, accuracy, quality standards and capsule sizes, among other vital aspects.
So, if you want to be an expert in liquid capsule filling machine, read this guide.
- What is a Liquid Capsule?
- What is Liquid Capsule Filling Machine?
- How does Liquid Capsule Filling Machine compare to Powder Capsule Filling Machine?
- What are the Parts of Liquid Capsule Filling Machine?
- How does Liquid Capsule Filling Machine Work?
- How do you Fill Liquid Capsules?
- What Liquid Material can you Fill using Liquid Capsule Filling Machine?
- What is Liquid Capsule Cover made of?
- What are the Benefits of Liquid Capsule?
- Why Invest in Liquid Capsule Filling Machine?
- Are there Limitations of Liquid Capsule Filling Machine?
- Are Liquid Capsules the same as Soft gel Capsules?
- What is the Accuracy of Liquid Filling Machine?
- How do you Select Excipients for a Liquid-Filled Hard Capsules?
- What are the Applications of Liquid-Filled Hard Capsules for Particular Drug Formulations?
- What are the Technical Specifications of Liquid Capsules Filling Machine?
- How does Manual Liquid Capsule Filling Machine compare to Fully Automatic Liquid Capsule Filling Machine?
- What Capsule Sizes can you Fill with Liquid Capsule Filling Machine?
- What are the Advantages of Semi-automatic Liquid Capsule Filling Machine?
- How long does it take for Liquid Capsule to Dissolve in your Stomach?
- How do Liquid Filled Capsules compare to Tablets?
- What are the Quality Standards for Liquid Capsules Filling Machine?
- Current Good Manufacturing Practice [cGMP] quality standard
- How much does Liquid Capsule Filling Machine Cost?
- How do you Maintain Liquid Capsules Filling Machine?
- What is Oil Capsule Filling Machine?
- What is the Latest Technology in Liquid Gel Capsule Filling Machine?
- Which Industries use Liquid Capsule Filling and Sealing Machine?
- Can you Fill Liquid alongside Solid Substances in Hard Gelatin Capsules?
- Which Material is Empty Capsules used in Liquid Filling Machine Made of?
- Is Liquid Filling Machine and Sealing Machine Available as Single Machine?
- Does Liquid Leak from Capsules after Filling?
- Why do you need Sealing Machine when using Liquid Capsule Filling Machine?
What is a Liquid Capsule?
A liquid capsule is a drug that has liquid or liquid and pellets inside the capsule.
A liquid capsule can come in two main categories:
· Hard-shelled Liquid Capsules
There are two pieces in a hard-shelled capsule.
You will use the liquid and the active ingredient in the capsule to hold the two pieces together.
You can have two drugs inside a hard-shelled capsule.
A hard-shelled liquid capsule is vacuum-sealed making it safe from sunlight and air in the environment.
A hard-shelled liquid capsule is also tampered and leak proof.
· Soft Gel Liquid Capsule
You will coat a soft gel liquid capsule with gelatin.
The composition of the gelatin is mainly a type of protein.
Since soft gel capsules are soft, they break down in the body easily and absorption takes place rapidly after ingestion.
The particles in a soft gel capsule can be tiny making it easy for the body to absorb the medicine efficiently and quickly.
It is easy to swallow a soft gel liquid capsule and it is tasteless.
A liquid-filled capsule also has a short shelf-life.
What is Liquid Capsule Filling Machine?
Liquid capsule filling machine
A liquid capsule filling machine is equipment that you will use in the industrial and pharmaceutical industries.
You can use a liquid capsule filling machine to hold paste or liquid inside empty capsules.
This machine combines high technology and an exclusive operation.
You can use a liquid capsule filling machine to fill the following combinations:
You will fill the capsule with just the liquid substance.
ii. Liquid and Pellets
The capsule will hold the liquid substance and some pellets.
iii. Liquid and Capsules
The capsule will hold the liquid substance and a small capsule.
iv. Liquid and a Small Capsule
The capsule will hold the liquid substance and a tablet or tablets.
How does Liquid Capsule Filling Machine compare to Powder Capsule Filling Machine?
A liquid capsule filling machine and a powder capsule filling machine differ in the substance they use to fill capsules.
You will use a liquid capsule filling machine to fill capsules with liquid substances or a paste.
You will use a powder capsule filling machine to fill capsules with powder or granule substances.
The hopper in a liquid capsule filling machine holds liquids while that of a powder capsule filling machine holds the powder.
Powder capsule filling machine
Liquid capsule filling machine
What are the Parts of Liquid Capsule Filling Machine?
A liquid capsule filling machine has many parts that work together in the filling of capsules.
These parts work with high precision technology and efficiency.
Here are the parts of a liquid capsule filling machine:
· Material Hopper
The material hopper will hold all the material and liquid that you will use to fill the capsules with.
· Capsule Hopper
The capsule hopper holds all the capsules that you will fill with the liquid capsule filler machine.
· Capsule Filling Part
Here, the capsule filling part positions the capsules that you are to fill in an upright direction.
The open side of the capsule faces upwards.
· Discharge Port
The discharge port channels out the liquid capsules that have liquid in them.
It directs the capsule to another part of the production unit for sealing.
· Servo Liquid Filling Part
The servo liquid filling part fills capsules with liquid.
A high precision ceramic pump ensures accurate small filling.
· Liquid Filling Seat
The liquid filling seat holds the capsules during the filling process.
· Rejection System
The rejection system works by removing any capsules that do not meet the set standards.
It rejects a capsule that has no filling at the end of the production unit.
It also rejects capsules that are either broken or tampered with.
· Mold Turnplate
The mold turn plate holds the capsules and circularly moves them towards each system in the machine.
Also, the mold turn plate moves the capsules from one part to the next once the capsule lands on it.
It ensures that the capsules move in a predictable direction and the correct range.
· Photoelectric Sensor
The photoelectric sensor faces every hole in the liquid capsule filling machine.
It makes sure that a capsule is inside the holes and that there is liquid material inside.
When it detects nothing, the rejection system takes charge.
How does Liquid Capsule Filling Machine Work?
A liquid capsule filling machine is accurate and efficient in the way it works.
All functions happen sequentially to ensure accurate filling of the capsules.
Each part of a liquid capsule filling machine has a specific duty to perform.
This ensures the best quality and high-standard liquid-filled capsules.
The capsule filling machine is fully enclosed by a transparent cover to ensure no contamination happens.
Also, the transparent cover also enables you to monitor all operations inside the capsule filling machine.
Before anything else, switch on the capsule filling machine.
Here is how a liquid capsule filling machine works:
Capsule Shell Loading
You will load the empty capsules on the hopper.
The empty capsules can come in different colors.
The capsules can be of varying sizes depending on the filling you are doing and the capsule recommendations.
For instance, capsules that you will fill with liquid and other materials can be large.
Capsule Shell Insertion and Separation
The empty capsules then move from the hopper.
The the capsule filling machine makes them be in an upright position.
The upright position is to ensure the liquid substance is filled with ease.
A photoelectric sensor also scans all the empty capsules to ensure they are in an upright position.
The capsules enter the machine body end first into the upper portion of split bushings or split filling rings.
A vacuum will pull the body down so that it enters the lower part of the machine.
The split bush has a wide diameter so that it can follow the body.
You will then separate the capsule to expose the body for filling.
The capsule filling machine can align them automatically before moving to the next stage.
Capsule Liquid Filling
In this stage, the empty capsules are filled with liquid substance and or with any other additional substances.
The machine fills the empty capsules with high precision pumps.
Besides, the high precision pumps ensure accuracy when filling the capsules with liquid.
The pumps also enable you to fill the empty capsules with small dosages.
Capsule liquid filling is an accurate process that allows a variety of within ± 1.5%.
The capsule filling machine uses a servo motor and not a stepping motor.
This is because a servo motor is of good quality and has linear oil-free bearings.
This reduces noise, vibration, and makes the machine to last for a long time.
Liquid Capsule Locking
In this stage, you will cover the capsules that are filled with the liquid substance.
Locking ensures that the components inside the capsule do not spill.
It also makes sure that no contamination happens to the liquid capsule.
You are to use the capsule caps to lock the liquid-filled capsules.
Liquid Capsule Discharge
You will move the capsules to the sealing station.
The capsules pass through the liquid capsule discharge to the liquid capsule sealing system.
Also, the liquid capsule discharge ensures that all capsules follow a set route.
The alignment of the capsules is done on this part as well.
Liquid Capsule Sealing
You will then seal the capsules once they leave the liquid capsule discharge.
A liquid capsule sealing system ensures that no leakages occur.
The liquid capsule sealing system applies a sealing ribbon at the center of the hard capsule.
It applies an even layer of gelatin around the capsule.
Too much of the seal makes the capsule not appealing and the drying process will take a long time.
Too little of the seal can break during mechanical shocks.
The rejection system removes any liquid-filled capsule that does not meet the set standards.
It has sensors that detect any substandard capsules.
This is to ensure that only capsules that are in the best condition move to the next stage.
You will not compromise the quality of the liquid-filled capsules by using the rejection system.
How do you Fill Liquid Capsules?
You will fill liquid capsules using a high precision pump.
These high precision pumps offer a lot of accuracy and efficiency.
Depending on the size of the liquid capsule, the pump will release the exact amount that you need to fill the capsule.
This ensures that the liquid capsule has the right capacity.
You can also fill a liquid capsule with a variety of liquid substances.
There is also the option of filling the liquid capsule with additional items such as pellets, small capsules, and tablets.
Liquid capsule filling station
What Liquid Material can you Fill using Liquid Capsule Filling Machine?
A liquid capsule filling machine has the advantage of filling many items inside the liquid capsule.
With this capability, you can make a variety of liquid capsules that meet international standards.
Since some drugs have water-insoluble molecules, the need for liquid drugs is increasing.
The liquid material increases drug solubility and bioavailability.
Besides, the liquid material also has to have a better viscosity level.
The liquid material can contain formulations such as lipids, surfactants, solvents, usually in a combination.
These are some of the liquid material you can fill using a liquid capsule filling machine:
- Oil solutions
- Liquid plant extracts
- Lipid formulations
- Fat-soluble fills
What is Liquid Capsule Cover made of?
A liquid capsule cover is an important component.
This is because it holds the liquid material and other substances.
You will make a liquid capsule cover with the right material and quality to ensure no contamination happens.
Recently, there has been a debate on whether the liquid capsule cover is non-vegetarian or vegetarian.
You can categorize capsule covers as vegetarian or non-vegetarian.
Gelatin, which comes from animals, makes up traditional capsules.
This comes from boiling the skin and the bones of pigs and cows.
A vegetarian capsule is an ideal choice as it has no preservatives, starch, sugar, or additional ingredients.
They are also easy to consume and are free from GMOs.
What are the Benefits of Liquid Capsule?
A liquid capsule has many benefits.
Many nutritional and pharmaceutical industries are using liquid-filled capsules.
This is because you can easily make drugs and supplements that are not that soluble.
It also gives you the advantage of lowering the time to develop them and also reduce costs.
Besides, liquid capsules can give you the ability to control R&D compounds.
R&D compounds are expensive and they are in low supply.
Here are the benefits of liquid capsules:
· Liquid Capsules are Better than Soft Gel Capsules
A liquid capsule has thin walls that allow for tiny capsule sizes. They are more efficient and dissolve easily than soft gels.
· Enhanced Absorption and Bioavailability
A liquid capsule is easy to dissolve as it in liquid form.
· Simple and Affordable Formulation
A liquid capsule does not need any form of plasticizers, binders, or lubricants found in traditional soft gels and solid-dosage forms.
You can fill liquid capsules with a water-soluble solution.
You can also fill a liquid capsule with a solution that is not water-soluble such as oils.
· Branding Opportunities
You can create countless combinations of various colors.
This makes you able to use your brand colors to mark the capsules uniquely.
This makes it easy to differentiate the products on the shelf.
· Tamper Proof
A liquid capsule has a barrier that does not allow water to penetrate.
This allows it to avoid any contamination before usage.
Why Invest in Liquid Capsule Filling Machine?
It is important to understand the benefits of a liquid capsule filling machine before you invest in one.
Here are some of the reasons why you should invest in a liquid capsule filling machine:
· Accuracy and Precision
You should invest in a liquid capsule filling machine a sit guarantees accurate and precise dosing.
This machine has an accuracy of 99.9% meaning no wastages will occur.
· Ease of Operation
A liquid capsule filling machine is also easy to operate.
A liquid capsule filling machine has the best materials to ensures low maintenance and that it lasts long.
· Improve Production
You can easily adjust the settings of a liquid capsule filling machine to improve production.
· Variety of Capsule Sizes
You can fill a wide range of capsule sizes with a liquid capsule filling machine.
You can use a liquid capsule filling machine to fill capsule sizes of 000#00#, 0#, 1#, 2#, 3#, and 4#.
You will save on the overall production cost as the machine will accomplish most tasks by itself.
This means you will need less human labor to monitor the filling process.
· Large Production Capacity
You will be able to fill a large number of capsules with a liquid capsule filling machine.
You can fill up to 18,000 pieces per hour.
· Liquid Filling Consistency
A liquid capsule filling machine guarantees you consistency when filling liquid capsules.
· Controlled Contamination
No contamination will occur as the machine is fully enclosed.
· Liquid Material Variation
You can use a liquid capsule filling machine to fill different kinds of liquids inside a liquid capsule.
· Making of Unique Capsules
You can make capsules of various colors with a liquid capsule filling machine.
You can also use seals that match the brand colors.
· Quality Production
A liquid capsule filling machine ensures that all liquid capsules meet the set international standards.
The machine has sensors that reject any liquid capsules that are substandard.
· Noise Level
The liquid capsule filling machine has low noise output levels.
Are there Limitations of Liquid Capsule Filling Machine?
Despite the advantages, a liquid capsule filling machine also has limitations to it.
These limitations should not deter you from investing in this machine.
Some of the limitation of a liquid capsule filling machine include:
· High Price
The initial price of a liquid capsule filling machine is generally high.
A fully automatic liquid capsule filling machine costs more than a semi-automatic liquid capsule filling machine.
Generally, a liquid capsule filling machine with a high production capacity also will cost you more.
A liquid capsule filling machine is only limited to liquids and paste.
You cannot use a liquid capsule filling machine to fill powders.
· Production Capacity
The production capacity of a liquid capsule filling machine varies a lot depending on the one you invest in.
The production capacity of the machine you choose depends on the budget you have.
If you need a high production capacity machine, you will need to spend more.
· Human Labor
The liquid capsule filling machine must have at least one person monitoring it.
This is true for both semi-automatic and fully automatic ones.
In a semi-automatic liquid capsule filling machine, the operator’s workload is high when you compare it to a fully automatic one.
Are Liquid Capsules the same as Soft gel Capsules?
No, liquid capsules are not the same as soft gel capsules.
You will join two pieces together in a liquid capsule while a soft gel is only one piece.
You will use a band to seal a liquid capsule.
Gelatin is the main material that makes up the outer shell of a soft gel capsule.
You can make a vegetarian and non-vegetarian liquid capsule.
Soft gel capsules are sensitive to water and heat which affects its shelf life.
On the other hand, a liquid capsule can withstand water content without affecting its physical property.
You can easily swallow soft gel capsules since it is flexible.
A liquid capsule is generally tasteless whereas you can sense some taste on the cover of the soft gel capsule.
A soft gel capsule is vulnerable to microbial growth since it has a high moisture content.
It is easy to cover liquid capsules than soft gel capsules.
A soft gel capsule disintegrates faster than a liquid capsule.
A soft gel capsule contains plasticizers that can enter into the content of the capsule
What is the Accuracy of Liquid Filling Machine?
A liquid capsule filling machine is one of the most accurate machines.
The accuracy ensures that no wastages occur when you are filling capsules.
A liquid capsule filling machine has high precision pumps and servo motors systems.
This maximizes the accuracy of filling liquid substances.
A liquid capsule liquid filling machine is accurate and only allows a difference that is within ± 2%.
How do you Select Excipients for a Liquid-Filled Hard Capsules?
A liquid-filled hard capsule has a shell of gelatin of hydroxypropyl methylcellulose.
You will then fill the capsule with compatible liquids that can flow below 70 oC.
The importance of choosing an excipient is to ensure that they are compatible with the capsule shell integrity.
Excipients also ensure that the capsule is suitable or the purpose of the formulation.
Some of the considerations when selecting excipients for a liquid-filled hard capsule are:
· Integrity of the Capsule Shell
A hard gelatin capsule has a moisture content of between 13–16%.
You cannot use hygroscopic vehicles like liquid polyethylene glycols (PEGs), glycerin, or propylene glycol by themselves.
The reason for this is that they will make the gelatin capsule shell to be brittle and fracture.
· Size of the Capsules
The capsule size limits:
- The dose of the drug substance
- The quality of the excipient that you can use to fill the capsule.
Generally, you are to fill the capsules to a 90% capacity to ensure proper filling and sealing of the liquid capsules.
Below is the liquid capacity of various liquid-filled hard capsules sizes:
Size 00 – 0.91 mL.
Size 0 – 0.68 mL.
Size 1 – 0.5 mL.
Size 2 – 0.37 mL.
Size 3 – 0.30 mL.
· Viscosity of the Liquid Material
It is recommended that the viscosity of the liquid material be within the range of 0.1–25 Pa•s (100–25000 cps).
This ensures a precise and accurate filling with the coefficient of variation (CV) of a fill-weight rate of lower than 1%.
· Cross-linking Potential
Cross-linking of gelatin can affect the dissolution of the capsule.
This can be due to low aldehydes concentration on some excipients that you will use in liquid-fill formulations.
It is important to research to minimize cross-linking.
You can classify the excipients compatible with liquid-filled hard capsules as follows:
Viscosity Modifiers and Semi-solid Lipophilic
- Hydrogenated oils
- Cetyl/stearyl alcohols
- Glyceryl esters
Emulsifiers, Solubilizers, Absorption Enhancers, and Surfactants
- Tween 80
- PEGs with MW exceeding 900 for HPMC capsules
- PEGs with MW exceeding 4000 for gelatin capsules
Lipophilic liquids include:
- Refined oils
What are the Applications of Liquid-Filled Hard Capsules for Particular Drug Formulations?
Here are some of the applications of a liquid-filled hard capsule for particular drug formulations:
- Potent drugs
- Abuse-resistant formulations
- Bioavailability enhancement
- Sustained release
- Hygroscopic drugs
- Avoiding the hepatic metabolic pathway for higher bioavailability
What are the Technical Specifications of Liquid Capsules Filling Machine?
The technical specifications of a liquid capsule filling machine will indicate the possibilities of the machine.
You can know the power consumption, capacity output, dimensions, filling accuracy, among others.
These technical specifications will help you decide if the machine will meet your needs.
Here are the technical specifications of a liquid capsule filling machine:
- A consumption output of up to 20,000 liquid capsules per hour.
- Filling accuracy of ±1.5%.
- Total power consumption of between 3KW and 9KW.
- The machine has an average weight of 2300 Kg.
- The machine has a dimension of approximately 3800(L) x900(W) x1800(H) mm.
- The machine uses a voltage specification of 380V, 3 phase 5 wire, 50 HZ.
How does Manual Liquid Capsule Filling Machine compare to Fully Automatic Liquid Capsule Filling Machine?
A manual liquid capsule filling machine is relatively cheap when you compare it to a fully automatic liquid capsule filling machine.
In a fully automatic liquid filling machine, there is the full automation of the liquid filling process.
The human workload you need in a manual capsule filling machine is greater than a fully automatic liquid capsule filling machine.
A fully automatic liquid capsule filling machine allows for a faster filing process than a manual machine.
A fully automatic capsule filling machine has a relatively higher output capacity than a manual machine.
There is less human involvement in a fully automatic liquid capsule filling machine.
A fully automatic liquid capsule filling machine has a higher power consumption than a manual machine.
A fully automatic liquid capsule machine has a PLC and touch screen HMI with the latest technology for ease of operation.
It is easy to use a fully automatic liquid capsule filling machine as it does the task by itself.
What Capsule Sizes can you Fill with Liquid Capsule Filling Machine?
You can fill a wide range of capsule sizes with a liquid capsule filling machine.
The size of the liquid capsule you will use depends on the volume of liquid you need.
Also, any additional material such as pellets and tablets, that you will include in the capsule determines the size.
The empty capsule sizes you can use are 000#00#, 0#, 1#, 2#, 3#, and 4#.
Capsule 4# is the smallest and the largest is 000#.
What are the Advantages of Semi-automatic Liquid Capsule Filling Machine?
A semi-automatic liquid capsule filling machine is generally a cheaper option than a fully automatic machine.
Here are some of the advantages of a semi-automatic liquid capsule filling machine:
A semi-automatic liquid capsule filling machine is cheap when you compare it to a fully automatic machine.
The budget you have and the needs you are to meet determine the kind of semi-automatic liquid capsule you can afford.
· Consistency in Production
A semi-automatic liquid capsule filling machine is more consistent when you compare it to a manual machine.
It can fill the liquid capsules uniformly and accurately.
This means that the quantity you fill in each capsule is the same all through the production line.
This machine is ideal when you want to fill a lot of liquid capsules within a short time.
· Ease of Use
A semi-automatic liquid capsule filling machine is easy to operate when you compare it to a manual machine.
You only need to have the necessary knowledge to understand how to operate the machine.
You can also control and monitor the machine by using a touch screen and buttons.
A semi-automatic liquid capsule filling machine is quite fast when it comes to filling liquid capsules.
This means you will save a lot of time when you use a semi-automatic liquid capsule filling machine.
In addition, it has a relatively high production capacity.
· Human Labor Involvement
A semi-automatic liquid capsule filling machine has less human workload.
This means the operator will not do a lot of things when the machine is filling liquid capsules.
A semi-automatic liquid capsule filling machine does not require a lot of space.
This means you can fit in comfortably in your production plant.
· Environmentally Friendly
A semi-automatic liquid capsule filling machine produces low noise levels, uses less energy, and is easy to maintain.
How long does it take for Liquid Capsule to Dissolve in your Stomach?
A liquid capsule takes approximately a few minutes to break down and the bloodstream to absorb it.
With this in mind, a liquid capsule is fast-acting and more powerful when you compare it to tablet pills.
In addition, the body may absorb the contents of a liquid capsule completely.
How do Liquid Filled Capsules compare to Tablets?
It is generally cheap to make tablets than it is to make liquid-filled capsules.
Tablets have a longer shelf life than capsules.
One tablet may have a higher dose of the active ingredient than a single capsule.
You can cut a tablet into two if you need to when consuming it which is not possible for liquid-filled capsules.
You can get tablets are chewable while liquid-filled capsules need to be swallowed whole.
Liquid-filled capsules break down rapidly than tablets meaning they offer you fast relief from symptoms.
Liquid filled capsules are generally tasteless and have no odor.
A liquid-filled tablet is resistant to tampering meaning you cannot split them in half as you would for tablets.
A liquid-filled capsule has a high bioavailability hence are more effective than tablets.
This means the mediation is highly likely to enter your bloodstreams.
What are the Quality Standards for Liquid Capsules Filling Machine?
A liquid capsule filling machine has to comply with quality standards to ensure safety, reliability, and quality.
The quality standards that a liquid capsule filling machine has to conform to include:
Current Good Manufacturing Practice [cGMP] quality standard
This quality standard ensures the machine uses proper design, control, and monitoring of manufacturing processes.
Adhering to cGMP assures the strength, quality, identity, and purity of the liquid capsules.
Restriction of Hazardous Substances [RoHS] quality standard
This quality standard ensures that no specific hazardous materials are on the machine.
This is to ensure the machine is environmentally friendly and does not cause any pollution.
CE Quality Standard
CE ensures the liquid capsule filling machine conforms with the safety, health, and environmental protection standards.
How much does Liquid Capsule Filling Machine Cost?
The cost of a liquid capsule filling machine depends on the type of machine you are looking for.
Generally, a fully automatic liquid capsule filling machine will cost more than a semi-automatic or a manual machine.
A liquid capsule filling machine will cost you anywhere from 70 US Dollars to 121,000 US Dollars.
How do you Maintain Liquid Capsules Filling Machine?
Maintaining a liquid capsule filling machine ensures that it meets your production needs and lasts for a long time.
You are to conduct frequent inspections on a liquid capsule filling machine.
You are to replace and or repair any broken or worn out parts.
You are to make sure that all electrical components are working properly and are in the best condition.
You are to clean the machine frequently.
You are to make sure all moving parts are not producing friction that will corrode the machine.
What is Oil Capsule Filling Machine?
An oil capsule filling machine is a machine that you will use to fill oil-based liquid inside capsules.
Some of the oils you can fill using an oil capsule filling machine include:
- Vitamin E oils
- Cod liver oil
- Fish oil
What is the Latest Technology in Liquid Gel Capsule Filling Machine?
The latest technology in liquid gel capsule filling machine addresses a wide range of difficult formulation challenges.
This technology makes it possible to produce innovative dosages.
The technology incorporates bio pharmaceutically-approved lipid and non-lipid excipients.
The achievement of this technology involves:
- Uniformity of dosages
- Better API stability
- Colonic delivery
- Abuse deterrent
- Enhancement of bioavailability
Which Industries use Liquid Capsule Filling and Sealing Machine?
The main industries that use a liquid capsule filling and sealing machine include:
- Pharmaceutical industries
- Health industries
- Food industries
Can you Fill Liquid alongside Solid Substances in Hard Gelatin Capsules?
Yes, you can fill liquid with other solid substances in hard gelatin capsules.
The filling you can have inside a liquid capsule include:
- The liquid substance alone
- The liquid substance and pellets
- The liquid substance and a small capsule
- The liquid substance and tablets
Which Material is Empty Capsules used in Liquid Filling Machine Made of?
You will use the same material that you use on regular capsules.
The materials are:
- Two-pieces of gelatin capsules
- Hydroxypropylmethylcellulose [HPMC] with a cap and a body
Is Liquid Filling Machine and Sealing Machine Available as Single Machine?
The filling material you are using will determine if you need both of these machines.
It is advisable to have a liquid filling machine as well as a sealing machine.
When you do not seal your liquid capsules, the liquid and contents may leak.
In rare instances, will you only need the liquid filling machine?
This is only possible for liquids with poor fluidity but it also needs time to prove in the long run.
Does Liquid Leak from Capsules after Filling?
After filling a liquid capsule, you place a cap on the body.
This prevents any leakages from happening.
In addition, when you fill and seal the liquid capsules, it will be airtight.
Sealed liquid capsule
Why do you need Sealing Machine when using Liquid Capsule Filling Machine?
You need a sealing machine to secure the liquid capsule after filling.
This ensures no leakages will happen.
In addition, it prevents any contamination from happening during storage or transportation.
At SaintyCo, we have a range of capsule filling machines depending on your unique specifications.
Whether you want a manual capsule filling machine, a fully automatic capsule filling machine, a semi-automatic capsule filling machine or a Softgel encapsulation machine, SaintyCo offers the perfect solution for you.
Contact us now for all your capsule filling needs.