{"id":7128,"date":"2019-05-31T09:15:50","date_gmt":"2019-05-31T09:15:50","guid":{"rendered":"https:\/\/www.saintyco.com\/?p=7128"},"modified":"2019-05-31T09:32:24","modified_gmt":"2019-05-31T09:32:24","slug":"soft-gelatin-capsule-formulation","status":"publish","type":"post","link":"https:\/\/www.saintyco.com\/cs\/formulace-mekkych-zelatinovych-kapsli\/","title":{"rendered":"Formulace m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed"},"content":{"rendered":"<p>Bez \u0159\u00e1dn\u00fdch znalost\u00ed o slo\u017een\u00ed m\u011bkk\u00fdch \u017eelatinov\u00fdch tobolek nem\u016f\u017eete investovat do pr\u016fmyslu Softgel.<\/p>\n<p>Nez\u00e1le\u017e\u00ed na tom, zda chcete investovat do <a href=\"https:\/\/www.saintytec.com\/cbd-oil\/\">Softgel oleje CBD<\/a>, dopln\u011bk stravy Softgel nebo l\u00e9k Softgel.<\/p>\n<p>Mus\u00edte p\u0159esn\u011b v\u011bd\u011bt, z \u010deho jsou m\u011bkk\u00e9 \u017eelatinov\u00e9 kapsle vyrobeny.<\/p>\n<p>V d\u016fsledku toho v tomto d\u00edle probereme n\u011bkolik probl\u00e9m\u016f t\u00fdkaj\u00edc\u00edch se m\u011bkk\u00e9 \u017eelatinov\u00e9 kapsle.<\/p>\n<p>Zde je letm\u00fd pohled na to, co byste m\u011bli o\u010dek\u00e1vat, v\u00fdhody, p\u0159\u00edsady, techniky klasifikace formulace, vybaven\u00ed pro formulaci a mnoho dal\u0161\u00edch.<\/p>\n<p>Okam\u017eit\u011b zah\u00e1j\u00edme na\u0161i diskusi.<\/p>\n<h2>Definice m\u011bkk\u00e9 \u017eelatinov\u00e9 kapsle?<\/h2>\n<p>Ne\u017e se pono\u0159\u00edte do definice, ve farmaceutick\u00e9m pr\u016fmyslu si v\u0161imnete, \u017ee praktici pod\u00e1vaj\u00ed l\u00e9ky odli\u0161n\u011b.<\/p>\n<p>Nejv\u00edce <a href=\"https:\/\/en.wikipedia.org\/wiki\/Dosage_form\">b\u011b\u017en\u00e9 l\u00e9kov\u00e9 formy<\/a> zahrnuj\u00ed tablety a kapsle.<\/p>\n<p>Kapsle jsou mal\u00e9 a v\u00e1lcovit\u00e9, zat\u00edmco tablety se li\u0161\u00ed tvarem a jsou kompaktn\u00ed.<\/p>\n<p>Kapsle lze op\u011bt rozd\u011blit na \u017eelatinov\u00e9 a vegetari\u00e1nsk\u00e9.<\/p>\n<p>P\u0159esto m\u016f\u017eeme \u017eelatinov\u00e9 tobolky rozd\u011blit do dvou t\u0159\u00edd, a to m\u011bkk\u00e9 a tvrd\u00e9.<\/p>\n<p>Poj\u010fme se nyn\u00ed oddat na\u0161\u00ed z\u00e1kladn\u00ed ot\u00e1zce.<\/p>\n<h3>Co je m\u011bkk\u00e1 \u017eelatinov\u00e1 kapsle?<\/h3>\n<p>Tud\u00ed\u017e m\u011bkk\u00e1 \u017eelatinov\u00e1 kapsle existuje v jedin\u00e9m nebo jednotkov\u00e9m kusu, tj. vn\u011bj\u0161\u00edm m\u011bkk\u00e9m obalu nebo pevn\u00e9 kapsli, kter\u00e1 obsahuje aktivn\u00ed l\u00e9\u010divo.<\/p>\n<p>Tento obal obvykle rychle taje, jakmile se v oblasti \u017ealudku roztav\u00ed.<\/p>\n<p><a href=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-1-Soft-gelatin-capsules.jpg\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-1-Soft-gelatin-capsules.jpg\" class=\"aligncenter size-full wp-image-7129 lazyload\" alt=\"M\u011bkk\u00e9 \u017eelatinov\u00e9 kapsle\" width=\"609\" height=\"393\"><noscript><img decoding=\"async\" class=\"aligncenter size-full wp-image-7129\" src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-1-Soft-gelatin-capsules.jpg\" alt=\"M\u011bkk\u00e9 \u017eelatinov\u00e9 kapsle\" width=\"609\" height=\"393\" srcset=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-1-Soft-gelatin-capsules.jpg 609w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-1-Soft-gelatin-capsules-300x194.jpg 300w\" sizes=\"(max-width: 609px) 100vw, 609px\" \/><\/noscript><\/a><\/p>\n<p style=\"text-align: center;\"><em>M\u011bkk\u00e9 \u017eelatinov\u00e9 kapsle<\/em><\/p>\n<p>Obvykle hladk\u00fd obal tobolky se skl\u00e1d\u00e1 z \u017eelatinov\u00e9ho materi\u00e1lu, proto se naz\u00fdv\u00e1 m\u011bkk\u00e1 \u017eelatinov\u00e1 tobolka.<\/p>\n<p>Sko\u0159\u00e1pka obsahuje prim\u00e1rn\u00ed l\u00e9\u010div\u00e9 hodnoty spolu s \u00fa\u010dinn\u00fdmi l\u00e1tkami.<\/p>\n<p>Je zvl\u00e1\u0161t\u011b vhodn\u00fd pro pou\u017eit\u00ed p\u0159i manipulaci s l\u00e9\u010div\u00fdmi p\u0159\u00edsadami, kter\u00e9 obsahuj\u00ed p\u0159ev\u00e1\u017en\u011b oleje, kapaln\u00e9, polotuh\u00e9 nebo v oleji rozpustn\u00e9 l\u00e9ky.<\/p>\n<p>Obecn\u011b se tedy na rozd\u00edl od typu tvrd\u00e9 \u017eelatiny skl\u00e1daj\u00ed z kapalin.<\/p>\n<p>Nav\u00edc m\u011bkk\u00e9 \u017eelatinov\u00e9 tobolky maj\u00ed r\u016fzn\u00e9 tvary, ale v\u011bt\u0161inou ov\u00e1ln\u00e9, kulovit\u00e9 a podlouhl\u00e9.<\/p>\n<p>Zaj\u00edmav\u00e9 je, \u017ee nikdy nemaj\u00ed p\u0159esn\u00fd pod\u00edl.<\/p>\n<p>B\u011bhem <a href=\"http:\/\/www.capsulefiller.com\/softgel-encapsulation-machine\/\">proces zapouzd\u0159en\u00ed<\/a>l\u00e9k\u00e1rn\u00edci vhodn\u011b sm\u00edchaj\u00ed l\u00e9ky se spr\u00e1vn\u00fdm mno\u017estv\u00edm rozpou\u0161t\u011bdla, kter\u00e9 existuje uvnit\u0159 vn\u011bj\u0161\u00edch obal\u016f.<\/p>\n<p><a href=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-2-Softgel-capsules.jpg\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-2-Softgel-capsules.jpg\" class=\"aligncenter size-full wp-image-7130 lazyload\" alt=\"Softgel kapsle\" width=\"717\" height=\"388\"><noscript><img decoding=\"async\" class=\"aligncenter size-full wp-image-7130\" src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-2-Softgel-capsules.jpg\" alt=\"Softgel kapsle\" width=\"717\" height=\"388\" srcset=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-2-Softgel-capsules.jpg 717w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-2-Softgel-capsules-300x162.jpg 300w\" sizes=\"(max-width: 717px) 100vw, 717px\" \/><\/noscript><\/a><\/p>\n<p style=\"text-align: center;\"><em>\u00a0Softgelov\u00e9 kapsle<\/em><\/p>\n<p>Voliteln\u011b by vn\u011bj\u0161\u00ed obal, obsah nebo dokonce oba tyto dva mohly obsahovat aktivn\u00ed slo\u017eku.<\/p>\n<p>V\u0161imn\u011bte si, \u017ee hlavn\u00ed slo\u017eka m\u016f\u017ee existovat ve form\u011b roztoku, n\u011bkter\u00e9 ve form\u011b suspenze nebo emulze.<\/p>\n<p>V\u0161echny tyto zp\u016fsoby poskytuj\u00ed rychlej\u0161\u00ed prost\u0159edky absorpce aktivn\u00ed slo\u017eky ve srovn\u00e1n\u00ed s jin\u00fdmi zp\u016fsoby dod\u00e1v\u00e1n\u00ed v tablet\u011b.<\/p>\n<p>M\u011bkk\u00e9 \u017eelatinov\u00e9 kapsle jsou skute\u010dn\u011b velmi obl\u00edben\u00e9 ve farmaceutick\u00e9m sektoru d\u00edky t\u011bmto jedine\u010dn\u00fdm vlastnostem.<\/p>\n<p>Nav\u00edc m\u011bkk\u00e9 \u017eelatinov\u00e9 kapsle p\u0159in\u00e1\u0161ej\u00ed n\u011bkolik v\u00fdhod spojen\u00fdch s pod\u00e1v\u00e1n\u00edm l\u00e9k\u016f.<\/p>\n<p>D\u00e1le se p\u0159esuneme d\u00e1le, abychom prozkoumali v\u00fdhody m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed.<\/p>\n<h2>V\u00fdhody m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed<\/h2>\n<p>N\u00e1sleduj\u00ed v\u00fdhody pou\u017eit\u00ed m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed.<\/p>\n<p><a href=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-3-CBD-Softgel.jpg\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-3-CBD-Softgel.jpg\" class=\"aligncenter size-full wp-image-7131 lazyload\" alt=\"CBD Softgel\" width=\"1200\" height=\"800\"><noscript><img decoding=\"async\" class=\"aligncenter size-full wp-image-7131\" src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-3-CBD-Softgel.jpg\" alt=\"CBD Softgel\" width=\"1200\" height=\"800\" srcset=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-3-CBD-Softgel.jpg 1200w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-3-CBD-Softgel-300x200.jpg 300w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-3-CBD-Softgel-768x512.jpg 768w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-3-CBD-Softgel-1024x683.jpg 1024w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/noscript><\/a><\/p>\n<p style=\"text-align: center;\"><em>CBD Softge<\/em>l<\/p>\n<ul>\n<li>Zvy\u0161uje rychlost vst\u0159eb\u00e1v\u00e1n\u00ed l\u00e9k\u016f. Vn\u011bj\u0161\u00ed obal se \u0159\u00e1dn\u011b rozpust\u00ed v \u017ealudku a uvoln\u00ed vysoce absorp\u010dn\u00ed l\u00e9\u010divou hodnotu, kter\u00e1 by n\u00e1sledn\u011b vyvolala v t\u011ble rychl\u00fd \u00fa\u010dinek.<\/li>\n<li>M\u011bkk\u00e9 gely poskytuj\u00ed lep\u0161\u00ed alternativu pod\u00e1v\u00e1n\u00ed \u0161patn\u011b rozpustn\u00fdch l\u00e9k\u016f prost\u0159ednictv\u00edm injekce kapaln\u00e9 \u0161ar\u017ee zam\u011b\u0159en\u00e9 na rychlej\u0161\u00ed rozpustnost.<\/li>\n<li>M\u011bkk\u00e9 gely zlep\u0161uj\u00ed biologickou dostupnost l\u00e9\u010div.<\/li>\n<li>Je u\u017eite\u010dn\u00fd p\u0159i dod\u00e1v\u00e1n\u00ed n\u00edzk\u00e9 slo\u017ekov\u00e9 d\u00e1vky l\u00e9\u010div\u00fdch slou\u010denin, jako jsou ty pro siln\u00e9 l\u00e9ky, \u010d\u00edm\u017e se sni\u017euje jeho variabilita v plazm\u011b. Tato technika vyhovuje d\u00e1vk\u00e1m ni\u017e\u0161\u00edm ne\u017e 100 mikrogram\u016f.<\/li>\n<li>M\u011bkk\u00e9 gely maskuj\u00ed chut\u011b a nep\u0159\u00edjemn\u00e9 pachy aktivn\u00ed slo\u017eky, a t\u00edm zvy\u0161uj\u00ed p\u0159\u00edjem pacient\u016f peror\u00e1ln\u011b.<\/li>\n<li>Pohodln\u011bj\u0161\u00ed polyk\u00e1n\u00ed d\u00edky m\u011bkk\u00e9 struktu\u0159e a flexibiln\u00edm tvar\u016fm na rozd\u00edl od tablet a nepot\u0159ebujete nutn\u011b doprovod, jako je voda.<\/li>\n<li>D\u00edky jedine\u010dn\u00fdm vlastnostem vn\u011bj\u0161\u00edho obalu obsahuj\u00ed m\u011bkk\u00e9 gely aktivn\u00ed slo\u017eku ze \u0161kodliv\u00fdch p\u0159\u00edm\u00fdch ultrafialov\u00fdch paprsk\u016f, kter\u00e9 mohou iniciovat oxidaci materi\u00e1lu.<\/li>\n<li>\u017delatinov\u00fd obal poskytuje vzduchot\u011bsn\u00e9 a bezpe\u010dn\u011bj\u0161\u00ed uzav\u0159en\u00ed v\u00fdpl\u0148ov\u00e9ho materi\u00e1lu.<\/li>\n<li>M\u011bkk\u00e9 gely maj\u00ed velmi p\u0159esn\u00fd a p\u0159esn\u00fd obsah, a tak dod\u00e1vaj\u00ed zam\u00fd\u0161lenou d\u00e1vku l\u00e9ku.<\/li>\n<li>M\u011bkk\u00e9 gely maj\u00ed neobvykl\u00fd a p\u0159\u00edjemn\u00fd vzhled.<\/li>\n<li>Zaji\u0161\u0165uje \u00fapln\u00e9 zapouzd\u0159en\u00ed prim\u00e1rn\u00edch slo\u017eek, \u010d\u00edm\u017e poskytuje syst\u00e9m odoln\u00fd proti neopr\u00e1vn\u011bn\u00e9 manipulaci.<\/li>\n<li>M\u011bkk\u00e9 gely lze p\u0159izp\u016fsobit tak, aby uvol\u0148ovaly sv\u016fj obsah na konkr\u00e9tn\u00edm m\u00edst\u011b v gastrointestin\u00e1ln\u00edm traktu.<\/li>\n<li>Barvy, tvary, laserov\u00e9 lept\u00e1n\u00ed a velikosti jsou snadno p\u0159izp\u016fsobiteln\u00e9 pomoc\u00ed m\u011bkk\u00fdch gel\u016f.<\/li>\n<\/ul>\n<p>Stru\u010dn\u011b \u0159e\u010deno, v\u0161echny tyto v\u00fdrazn\u00e9 v\u00fdhody \u010din\u00ed z m\u011bkk\u00fdch gel\u016f velmi vhodn\u00fd zp\u016fsob dod\u00e1v\u00e1n\u00ed <a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/drug-oxidation\">oxidovan\u00e9 l\u00e9ky<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18621492\">hydrofobn\u00ed l\u00e9ky<\/a>, <a href=\"https:\/\/www.pharmatutor.org\/articles\/an-overview-melt-in-mouth-tablets\">snadno roztaviteln\u00e9 l\u00e9ky<\/a>a produkty zdravotn\u00ed p\u00e9\u010de.<\/p>\n<p>Tyto v\u00fdhody v\u0161ak maj\u00ed tendenci zast\u00ednit nedostatky m\u011bkk\u00fdch gel\u016f.<\/p>\n<p>Ve skute\u010dnosti maj\u00ed tak\u00e9 sv\u016fj pod\u00edl na jejich kritice.<\/p>\n<p><a href=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-4-CBD-Soft-gelatin-capsules.jpg\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-4-CBD-Soft-gelatin-capsules.jpg\" class=\"aligncenter size-full wp-image-7132 lazyload\" alt=\"CBD m\u011bkk\u00e9 \u017eelatinov\u00e9 kapsle\" width=\"600\" height=\"600\"><noscript><img decoding=\"async\" class=\"aligncenter size-full wp-image-7132\" src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-4-CBD-Soft-gelatin-capsules.jpg\" alt=\"CBD m\u011bkk\u00e9 \u017eelatinov\u00e9 kapsle\" width=\"600\" height=\"600\" srcset=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-4-CBD-Soft-gelatin-capsules.jpg 600w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-4-CBD-Soft-gelatin-capsules-150x150.jpg 150w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-4-CBD-Soft-gelatin-capsules-300x300.jpg 300w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-4-CBD-Soft-gelatin-capsules-66x66.jpg 66w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-4-CBD-Soft-gelatin-capsules-45x45.jpg 45w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/noscript><\/a><\/p>\n<p style=\"text-align: center;\"><em>CBD m\u011bkk\u00e9 \u017eelatinov\u00e9 kapsle<\/em><\/p>\n<ul>\n<li>Kv\u016fli ur\u010dit\u00fdm omezen\u00edm existuje na cel\u00e9m sv\u011bt\u011b pouze n\u011bkolik skute\u010dn\u00fdch v\u00fdrobc\u016f m\u011bkk\u00fdch gel\u016f.<\/li>\n<li>P\u0159\u00edpravy m\u011bkk\u00fdch gel\u016f jsou pom\u011brn\u011b n\u00e1kladn\u00e9, proto\u017ee jsou omezeny pouze na velk\u00e9 mno\u017estv\u00ed kv\u016fli pou\u017eit\u00e9mu high-tech vybaven\u00ed.<\/li>\n<li>M\u011bkk\u00e9 gely jsou velmi citliv\u00e9 na teplo a vlhkost. Znamen\u00e1 to tedy, \u017ee byste m\u011bli b\u00fdt p\u0159i jejich skladov\u00e1n\u00ed opatrn\u00ed, zejm\u00e9na v hork\u00fdch nebo vlhk\u00fdch klimatick\u00fdch oblastech. V opa\u010dn\u00e9m p\u0159\u00edpad\u011b se mohou p\u0159ilepit nebo prasknout.<\/li>\n<li>P\u0159edstavuj\u00ed dietn\u00ed omezen\u00ed. \u017delatinov\u00fdm materi\u00e1lem jsou ohromn\u011b kravsk\u00e9 nebo prase\u010d\u00ed kosti a k\u016f\u017ee. N\u011bkter\u00e1 n\u00e1bo\u017eenstv\u00ed, jako jsou \u017eid\u00e9, muslimov\u00e9 a hinduist\u00e9, bohu\u017eel od konzumace t\u011bchto \u017eivo\u010di\u0161n\u00fdch produkt\u016f odrazuj\u00ed. Krom\u011b toho je \u00fapln\u00ed vegetari\u00e1ni jen t\u011b\u017eko pou\u017e\u00edvaj\u00ed.<\/li>\n<\/ul>\n<p>Nyn\u00ed ji\u017e zn\u00e1te d\u016fvody, pro\u010d v\u011bt\u0161ina farmaceutick\u00e9ho pr\u016fmyslu st\u00e1le v\u00edce vol\u00ed m\u011bkk\u00e9 gely.<\/p>\n<p>Ji\u017e jsme nazna\u010dili, \u017ee m\u011bkk\u00e9 gely velmi spol\u00e9haj\u00ed na \u017eelatinov\u00fd materi\u00e1l.<\/p>\n<p>Krom\u011b \u017eelatiny hraj\u00ed p\u0159i v\u00fdrob\u011b kapsl\u00ed v\u00fdznamnou roli i dal\u0161\u00ed materi\u00e1ly.<\/p>\n<p>Jak\u00e9 jsou tedy tyto ingredience?<\/p>\n<p>Pokra\u010dujte ve \u010dten\u00ed, abyste se o tom dozv\u011bd\u011bli v\u00edce v dal\u0161\u00ed \u010d\u00e1sti.<\/p>\n<h2>Slo\u017een\u00ed m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed<\/h2>\n<p>Nyn\u00ed si mus\u00edte b\u00fdt v\u011bdomi toho, \u017ee cel\u00e1 m\u011bkk\u00e1 gelov\u00e1 kapsle se skl\u00e1d\u00e1 z vn\u011bj\u0161\u00edho obalu a v\u00fdpl\u0148ov\u00e9ho materi\u00e1lu.<\/p>\n<p>Ka\u017ed\u00fd z t\u011bchto odd\u00edl\u016f m\u00e1 sv\u00e9 jedine\u010dn\u00e9 slo\u017een\u00ed.<\/p>\n<p>Nyn\u00ed analyzujeme ka\u017edou mo\u017enou slo\u017eku cel\u00fdch \u010d\u00e1st\u00ed kapsle.<\/p>\n<p><a href=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-5-Structure-of-soft-gelatin-capsules.jpg\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-5-Structure-of-soft-gelatin-capsules.jpg\" class=\"aligncenter size-full wp-image-7133 lazyload\" alt=\"Struktura m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed\" width=\"653\" height=\"404\"><noscript><img decoding=\"async\" class=\"aligncenter size-full wp-image-7133\" src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-5-Structure-of-soft-gelatin-capsules.jpg\" alt=\"Struktura m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed\" width=\"653\" height=\"404\" srcset=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-5-Structure-of-soft-gelatin-capsules.jpg 653w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-5-Structure-of-soft-gelatin-capsules-300x186.jpg 300w\" sizes=\"(max-width: 653px) 100vw, 653px\" \/><\/noscript><\/a><\/p>\n<p style=\"text-align: center;\"><em>\u00a0Struktura m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed<\/em><\/p>\n<h3>1. Vn\u011bj\u0161\u00ed obal m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed<\/h3>\n<p>Tvo\u0159\u00ed nejz\u00e1kladn\u011bj\u0161\u00ed slo\u017eku formulace m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed.<\/p>\n<p>Pl\u00e1\u0161\u0165 obsahuje \u0159adu komponent; mezi hlavn\u00ed pat\u0159\u00ed \u017eelatina, zm\u011bk\u010dovadlo, sm\u011bs zm\u011bk\u010dovadel a voda.<\/p>\n<p>Krom\u011b toho se m\u016f\u017ee skl\u00e1dat z konzerva\u010dn\u00edch l\u00e1tek, barviv, kalic\u00edch l\u00e1tek, p\u0159\u00edchut\u00ed, sladidel, gastrorezistentn\u00edch produkt\u016f atd.<\/p>\n<p>Uv\u011bdomujete si, \u017ee t\u011bchto slo\u017eek je mnoho, co\u017e znamen\u00e1, \u017ee se v t\u00e9to p\u0159\u00edru\u010dce nem\u016f\u017eeme pono\u0159it do v\u0161ech.<\/p>\n<p>V z\u00e1jmu na\u0161\u00ed diskuse se zam\u011b\u0159\u00edme na podstatn\u00e9 prvky.<\/p>\n<p>za\u010d\u00edn\u00e1me.<\/p>\n<h3><em>\u00b7 \u017delatina pro slo\u017een\u00ed m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed<\/em><\/h3>\n<p>\u017delatina je organick\u00fd potravin\u00e1\u0159sk\u00fd materi\u00e1l bez chuti obsahuj\u00edc\u00ed kolagen.<\/p>\n<p>Hlavn\u00edm zdrojem tohoto extraktu jsou zv\u00ed\u0159ata.<\/p>\n<p>M\u016f\u017eete jej z\u00edskat p\u0159edev\u0161\u00edm ze zv\u00ed\u0159ec\u00edch kost\u00ed a k\u016f\u017e\u00ed.<\/p>\n<p>V\u011bdci \u00fadajn\u011b preferuj\u00ed z\u00edsk\u00e1v\u00e1n\u00ed takov\u00fdch produkt\u016f od prasat a krav.<\/p>\n<p><a href=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-6-Gelatin.jpg\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-6-Gelatin.jpg\" class=\"aligncenter size-full wp-image-7134 lazyload\" alt=\"\u017delatina\" width=\"570\" height=\"375\"><noscript><img decoding=\"async\" class=\"aligncenter size-full wp-image-7134\" src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-6-Gelatin.jpg\" alt=\"\u017delatina\" width=\"570\" height=\"375\" srcset=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-6-Gelatin.jpg 570w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-6-Gelatin-300x197.jpg 300w\" sizes=\"(max-width: 570px) 100vw, 570px\" \/><\/noscript><\/a><\/p>\n<p style=\"text-align: center;\"><em>Tekut\u00e1 \u017eelatina<\/em><\/p>\n<p>Synt\u00e9za \u017eelatiny z kost\u00ed a k\u016f\u017ee samoz\u0159ejm\u011b nen\u00ed tak p\u0159\u00edmo\u010dar\u00fd proces.<\/p>\n<p>Vy\u017eadovali byste to ud\u011blat v l\u00e9k\u00e1rn\u011b pomoc\u00ed n\u011bjak\u00e9ho za\u0159\u00edzen\u00ed, odborn\u00edk by tento \u00fakol usnadnil.<\/p>\n<p>N\u00e1sledn\u011b, vzhledem k rozd\u00edlu ve v\u00fdrob\u011b \u017eelatin, jsou k dispozici dva hlavn\u00ed typy.<\/p>\n<p>Prvn\u00ed typ zahrnuje v\u00fdrobu \u017eelatiny hydrol\u00fdzou zv\u00ed\u0159ec\u00edch k\u016f\u017e\u00ed pomoc\u00ed kysel\u00e9ho roztoku.<\/p>\n<p>P\u0159i\u010dem\u017e dal\u0161\u00ed spo\u010d\u00edv\u00e1 ve v\u00fdrob\u011b pomoc\u00ed z\u00e1kladn\u00ed hydrol\u00fdzy hov\u011bz\u00edch kost\u00ed.<\/p>\n<p>D\u016fle\u017eit\u00e9 je, \u017ee s pokrokem technologie je k dispozici spr\u00e1vn\u00e1 n\u00e1hrada za \u017eelatinov\u00e9 kapsle.<\/p>\n<p>Vegetari\u00e1ni a v\u011b\u0159\u00edc\u00ed lid\u00e9 se nyn\u00ed mohou rozhodnout pro vegetari\u00e1nsk\u00e9 kapsle vyroben\u00e9 z \u010dist\u00fdch rostlin a rostlinn\u00fdch produkt\u016f.<\/p>\n<p>To by m\u011bla b\u00fdt \u00faleva pro obrovsk\u00e9 mno\u017estv\u00ed takov\u00fdch lid\u00ed.<\/p>\n<h3><em>\u00b7 Zm\u011bk\u010dovadla ve slo\u017een\u00ed m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed<\/em><\/h3>\n<p>Pod\u00edvejte se pozorn\u011b na m\u011bkk\u00fd gel; v\u0161imnete si jeho hladk\u00e9ho, elastick\u00e9ho a poddajn\u00e9ho vn\u011bj\u0161\u00edho krytu.<\/p>\n<p>Tyto vlastnosti jsou mo\u017en\u00e9 pouze p\u0159i pou\u017eit\u00ed vhodn\u00e9ho zm\u011bk\u010dovadla.<\/p>\n<p>Zm\u011bk\u010dovadla v\u00fdznamn\u011b tvo\u0159\u00ed velkou \u010d\u00e1st kapsle \u2014 obvykle p\u0159ibli\u017en\u011b 20 \u2013 30 % m\u011bkk\u00e9ho gelu.<\/p>\n<p><a href=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-7-Structure-of-softgel.jpg\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-7-Structure-of-softgel.jpg\" class=\"aligncenter size-full wp-image-7135 lazyload\" alt=\"Struktura softgelu\" width=\"625\" height=\"414\"><noscript><img decoding=\"async\" class=\"aligncenter size-full wp-image-7135\" src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-7-Structure-of-softgel.jpg\" alt=\"Struktura softgelu\" width=\"625\" height=\"414\" srcset=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-7-Structure-of-softgel.jpg 625w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-7-Structure-of-softgel-300x199.jpg 300w\" sizes=\"(max-width: 625px) 100vw, 625px\" \/><\/noscript><\/a><\/p>\n<p style=\"text-align: center;\"><em>Struktura Softgelu \u2013 Foto s laskav\u00fdm svolen\u00edm: Mahesh<\/em><\/p>\n<p>B\u011b\u017en\u011b dostupn\u00fdm zm\u011bk\u010dovadlem je glycerol.<\/p>\n<p>Krom\u011b toho mnoho l\u00e9k\u00e1rn\u00edk\u016f pou\u017e\u00edv\u00e1 sorbitol a propylenglykol-400, ale pouze po sm\u00edch\u00e1n\u00ed s glycerolem.<\/p>\n<p>P\u0159\u00edsp\u011bvky zm\u011bk\u010dovadel ke kone\u010dn\u00e9mu produktu jsou velmi z\u00e1sadn\u00ed, tak\u017ee mus\u00edte b\u00fdt velmi ostra\u017eit\u00ed, abyste to ud\u011blali spr\u00e1vn\u011b.<\/p>\n<p>Pro\u010d?<\/p>\n<p>Textura, rozpu\u0161t\u011bn\u00ed a rozpad p\u0159\u00edpadn\u00e9ho m\u011bkk\u00e9ho gelu se budou li\u0161it v z\u00e1vislosti na druhu zm\u011bk\u010dovadla, kter\u00e9 pou\u017e\u00edv\u00e1te.<\/p>\n<p>Ve skute\u010dnosti m\u016f\u017ee m\u00edt vliv na zm\u011bnu jeho fyzik\u00e1ln\u00ed a chemick\u00e9 stability.<\/p>\n<p>Z\u00e1v\u011brem je, \u017ee spr\u00e1vn\u00fd typ zm\u011bk\u010dovadla a jeho koncentrace by m\u011bly zaru\u010dit odpov\u00eddaj\u00edc\u00ed kompatibilitu sko\u0159\u00e1pky a v\u00fdpl\u0148ov\u00e9ho materi\u00e1lu.<\/p>\n<h3><em>\u00b7 Voda ve slo\u017een\u00ed m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed<\/em><\/h3>\n<p>Voda je nepopirateln\u011b nezbytnou sou\u010d\u00e1st\u00ed sko\u0159\u00e1pky. Zab\u00edr\u00e1 velkou \u010d\u00e1st p\u0159ibli\u017en\u011b 30 \u2013 40 % formulace.<\/p>\n<p>Voda je rozhoduj\u00edc\u00edm rozpou\u0161t\u011bdlem pro zpracov\u00e1n\u00ed, konkr\u00e9tn\u011b p\u0159i p\u0159\u00edprav\u011b gelu spolu s enkapsulac\u00ed.<\/p>\n<p>Tento obsah vody poskytuje kapsl\u00edm dostate\u010dnou turgiditu.<\/p>\n<p>Tato stabilita p\u0159ich\u00e1z\u00ed na \u0159adu p\u0159i kol\u00eds\u00e1n\u00ed podm\u00ednek skladov\u00e1n\u00ed, kdy si kapsle pot\u0159ebuj\u00ed zachovat sv\u00e9 fyzik\u00e1ln\u00ed vlastnosti.<\/p>\n<h3><em>\u00b7 Opacifik\u00e1tory ve slo\u017een\u00ed m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed<\/em><\/h3>\n<p>V p\u0159\u00edpadech, kdy je n\u00e1pl\u0148ov\u00e1 formulace suspenzn\u00ed nebo dokonce citliv\u00e1 na sv\u011btlo, pak m\u016f\u017eete pou\u017e\u00edt kalidlo, v\u00fdhodn\u011b oxid titani\u010dit\u00fd.<\/p>\n<p>Opacifik\u00e1tor iniciuje tvorbu siln\u00e9ho krytu.<\/p>\n<p>Krom\u011b toho naru\u0161uje jakoukoli potenci\u00e1ln\u00ed fotodegradaci slo\u017eek citliv\u00fdch na sv\u011btlo.<\/p>\n<p>Pou\u017eit\u00ed oxidu titani\u010dit\u00e9ho jako samostatn\u00e9 slo\u017eky vede k vytvo\u0159en\u00ed b\u00edl\u00e9, ale nepr\u016fhledn\u00e9 sko\u0159\u00e1pky.<\/p>\n<p>Jinde, kdy\u017e zabudujete dal\u0161\u00ed substituenty, z\u00edsk\u00e1te barevn\u00fd.<\/p>\n<h3><em>\u00b7 Barviva pro m\u011bkk\u00e9 \u017eelatinov\u00e9 kapsle<\/em><\/h3>\n<p>Barviva vykon\u00e1vaj\u00ed p\u0159\u00edm\u00fd \u00fakol; d\u00e1vaj\u00ed sko\u0159\u00e1pk\u00e1m po\u017eadovanou barvu, co\u017e v\u00e1m zase pom\u016f\u017ee rychle identifikovat va\u0161e tobolky.<\/p>\n<p><a href=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-8-Different-colors-of-softgel-capsules.jpg\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-8-Different-colors-of-softgel-capsules.jpg\" class=\"aligncenter size-full wp-image-7136 lazyload\" alt=\"R\u016fzn\u00e9 barvy m\u011bkk\u00fdch kapsl\u00ed\" width=\"723\" height=\"228\"><noscript><img decoding=\"async\" class=\"aligncenter size-full wp-image-7136\" src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-8-Different-colors-of-softgel-capsules.jpg\" alt=\"R\u016fzn\u00e9 barvy m\u011bkk\u00fdch kapsl\u00ed\" width=\"723\" height=\"228\" srcset=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-8-Different-colors-of-softgel-capsules.jpg 723w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-8-Different-colors-of-softgel-capsules-300x95.jpg 300w\" sizes=\"(max-width: 723px) 100vw, 723px\" \/><\/noscript><\/a><\/p>\n<p style=\"text-align: center;\"><em>R\u016fzn\u00e9 barvy kapsl\u00ed Softgel<\/em><\/p>\n<p>V\u0161imn\u011bte si, \u017ee barviva jsou k dispozici ve dvou variant\u00e1ch, tj. syntetick\u00e1 a p\u0159\u00edrodn\u00ed.<\/p>\n<p>V\u00fdb\u011br mezi t\u011bmito dv\u011bma by nem\u011bl b\u00fdt t\u011b\u017ek\u00fd \u00fakol.<\/p>\n<p>V\u0161e z\u00e1vis\u00ed na z\u00e1kazn\u00edkov\u011b preferenci nebo zaujatosti v\u016f\u010di syntetick\u00fdm produkt\u016fm nebo p\u0159\u00edrodn\u00edm.<\/p>\n<h3><em>\u00b7 Konzerva\u010dn\u00ed l\u00e1tky ve slo\u017een\u00ed m\u011bkk\u00fdch gelov\u00fdch kapsl\u00ed<\/em><\/h3>\n<p>Konzervanty jsou v nepatrn\u00e9m mno\u017estv\u00ed, p\u0159esto pln\u00ed \u017eivotn\u011b d\u016fle\u017eitou funkci. B\u011b\u017en\u00e9 jsou methylparaben nebo propylparaben.<\/p>\n<p>Udr\u017euj\u00ed pod kontrolou l\u00e9\u010divou hodnotu l\u00e9ku a br\u00e1n\u00ed jak\u00e9koli hroz\u00edc\u00ed interferenci od mikrob\u016f.<\/p>\n<p>Konzerva\u010dn\u00ed l\u00e1tky p\u0159isp\u00edvaj\u00ed p\u0159ibli\u017en\u011b k 0,2 % koncentrace cel\u00e9 l\u00e9\u010div\u00e9 kapacity.<\/p>\n<h3><em>\u00b7 Aromatiza\u010dn\u00ed l\u00e1tky v m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00edch<\/em><\/h3>\n<p>Pamatujte, \u017ee jsme ji\u017e d\u0159\u00edve nazna\u010dili, \u017ee m\u011bkk\u00e9 gely maskuj\u00ed nep\u0159\u00edjemnou chu\u0165 l\u00e9k\u016f.<\/p>\n<p>To je mo\u017en\u00e9 d\u00edky dochucovadl\u016fm.<\/p>\n<p>Na v\u00fdb\u011br m\u00e1te dlouh\u00fd seznam t\u011bchto produkt\u016f. Pozoruhodn\u00fdmi p\u0159\u00edklady jsou \u00e9terick\u00e9 oleje, ethylvanilin, sachar\u00f3za atd.<\/p>\n<h3>2. Napl\u0148te materi\u00e1l formulac\u00ed m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed<\/h3>\n<p>Na rozd\u00edl od pl\u00e1\u0161t\u011b je slo\u017een\u00ed n\u00e1pln\u011b jedine\u010dn\u00e9 a m\u011bn\u00ed se podle pot\u0159eb v\u00fdrobce.<\/p>\n<p>To znamen\u00e1, \u017ee ka\u017ed\u00fd v\u00fdpl\u0148ov\u00fd materi\u00e1l se li\u0161\u00ed svou specializac\u00ed, aby bylo dosa\u017eeno zam\u00fd\u0161len\u00e9 optim\u00e1ln\u00ed terapeutick\u00e9 hodnoty.<\/p>\n<div class=\"ast-oembed-container\" style=\"height: 100%;\"><iframe class=\"lazyload\" data-src=\"https:\/\/www.youtube.com\/embed\/HczsxFt15z8?feature=oembed\" title=\"Aprila SG250 Stroj na zapouzd\u0159en\u00ed zeleninov\u00fdch m\u011bkk\u00fdch gel\u016f\" width=\"500\" height=\"375\"  frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>B\u011bhem formulace mus\u00edte v\u00e1\u017en\u011b p\u0159ehodnotit chemickou stabilitu aktivn\u00ed slo\u017eky.<\/p>\n<p>Nen\u00ed to jen konven\u010dn\u00ed v\u00fdrobn\u00ed postup, ale p\u0159edev\u0161\u00edm se t\u00edm zlep\u0161uje biologick\u00e1 dostupnost l\u00e9\u010diva.<\/p>\n<p>Krom\u011b toho existuje jak\u00e1koli konven\u010dn\u00ed v\u00fdpl\u0148 ve t\u0159ech prim\u00e1rn\u00edch typech.<\/p>\n<p>Pod\u00edvejte se.<\/p>\n<p><strong>i.<\/strong> \u010cist\u00e9 komponenty, jako je olejov\u00e1 kapalina<\/p>\n<p><strong>ii.<\/strong> \u0158e\u0161en\u00ed<\/p>\n<p><strong>iii.<\/strong> suspenze<\/p>\n<p>T\u00edm to nekon\u010d\u00ed; mus\u00edte pou\u017e\u00edt \u00fa\u010dinnou techniku pln\u011bn\u00ed, kter\u00e1 zaru\u010duje p\u0159esn\u00e9 m\u011b\u0159en\u00ed p\u0159i dosa\u017een\u00ed stabiln\u00ed kapsle.<\/p>\n<p>To je v\u0161e. To jsou va\u0161e c\u00edlov\u00e9 slo\u017eky ka\u017ed\u00e9 m\u011bkk\u00e9 gelov\u00e9 kapsle.<\/p>\n<p>Dal\u0161\u00ed segment je stejn\u011b informativn\u00ed a stejn\u011b tak technick\u00fd. To si nem\u016f\u017eete nechat uj\u00edt.<\/p>\n<p>Pokra\u010dujte ve \u010dten\u00ed.<\/p>\n<h3>3. Techniky formulace m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed<\/h3>\n<p>B\u011bhem formulac\u00ed mus\u00edte db\u00e1t mimo\u0159\u00e1dn\u00e9 opatrnosti a ostra\u017eitosti, proto\u017ee se jedn\u00e1 o n\u00e1ro\u010dn\u00fd technick\u00fd postup.<\/p>\n<p>Zde je z\u00e1kladn\u00ed n\u00e1vrh slo\u017een\u00ed m\u011bkk\u00e9ho gelu, kter\u00fd nevylu\u010dujete.<\/p>\n<p>V\u017edy se ujist\u011bte, \u017ee interakce nebo migrace mezi kapalinou\/polokapalnou n\u00e1pln\u00ed a vn\u011bj\u0161\u00edm pl\u00e1\u0161t\u011bm jsou velmi zanedbateln\u00e9.<\/p>\n<p>Nyn\u00ed je to v tomto bod\u011b, \u017ee volba typu zm\u011bk\u010dovadla hraje ned\u00edlnou roli.<\/p>\n<p>Proto jsou to pr\u00e1v\u011b tyto interakce sko\u0159\u00e1pky a v\u00fdpln\u011b, kter\u00e9 se formula\u010dn\u00ed techniky sna\u017e\u00ed identifikovat a zabr\u00e1nit jim.<\/p>\n<p>Op\u011bt plat\u00ed, \u017ee takov\u00e9 interakce jsou nejb\u011b\u017en\u011bj\u0161\u00ed b\u011bhem v\u00fdrobn\u00edho procesu, su\u0161en\u00ed nebo skladov\u00e1n\u00ed.<\/p>\n<p>Schopnost identifikovat a kontrolovat m\u00edru t\u011bchto interakc\u00ed je pro v\u00e1s v\u00fdhodou.<\/p>\n<p>Pro\u010d?<\/p>\n<p>Tento druh interakc\u00ed ohro\u017euje stabilitu kone\u010dn\u00e9ho produktu.<\/p>\n<p>S ohledem na to v\u0161echno se nyn\u00ed m\u016f\u017eeme pono\u0159it do dvou mu\u010div\u00fdch typ\u016f interakc\u00ed.<\/p>\n<p>Jsou n\u00e1sleduj\u00edc\u00ed.<\/p>\n<ul>\n<li>Chemick\u00e9 reakce<\/li>\n<li>Fyzick\u00e9 interakce<\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-9-Soft-gel-capsules-manufacturing.jpg\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-9-Soft-gel-capsules-manufacturing.jpg\" class=\"aligncenter size-full wp-image-7138 lazyload\" alt=\"V\u00fdroba m\u011bkk\u00fdch gelov\u00fdch kapsl\u00ed\" width=\"744\" height=\"432\"><noscript><img decoding=\"async\" class=\"aligncenter size-full wp-image-7138\" src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-9-Soft-gel-capsules-manufacturing.jpg\" alt=\"V\u00fdroba m\u011bkk\u00fdch gelov\u00fdch kapsl\u00ed\" width=\"744\" height=\"432\" srcset=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-9-Soft-gel-capsules-manufacturing.jpg 744w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-9-Soft-gel-capsules-manufacturing-300x174.jpg 300w\" sizes=\"(max-width: 744px) 100vw, 744px\" \/><\/noscript><\/a><\/p>\n<p style=\"text-align: center;\"><em>\u00a0V\u00fdroba m\u011bkk\u00fdch kapsl\u00ed \u2013 Foto s laskav\u00fdm svolen\u00edm: BIOPHARMA ASIA<\/em><\/p>\n<p>Pro nekomplikovan\u00e9 pochopen\u00ed rozd\u011bl\u00edm ka\u017ed\u00fd do jednoduch\u00e9 diskuse.<\/p>\n<h3><em>\u00b7 Chemick\u00e1 reakce ve formulaci m\u011bkk\u00fdch gelov\u00fdch kapsl\u00ed<\/em><\/h3>\n<p>Chemick\u00e1 reakce zahrnuje n\u011bkolik reakc\u00ed, kter\u00e9 mohou nastat mezi matric\u00ed n\u00e1pln\u011b proti \u017eelatin\u011b a zm\u011bk\u010dovadlem.<\/p>\n<p>Obecn\u011b tedy zahrnuje slo\u017eky v\u00fdpl\u0148ov\u00e9 matrice spolu se slo\u017ekami vn\u011bj\u0161\u00edho obalu.<\/p>\n<p>Vezm\u011bme si nap\u0159\u00edklad b\u011bhem procesu zapouzd\u0159en\u00ed; \u017eelatina m\u016f\u017ee podl\u00e9hat zes\u00edt\u011bn\u00ed, pokud aktivn\u00ed slo\u017eka obsahuje reaktivn\u00ed skupiny prvk\u016f, jako je aldehyd.<\/p>\n<p>Tento probl\u00e9m m\u016f\u017eete vy\u0159e\u0161it pouze pou\u017eit\u00edm sukcinylovan\u00e9 \u017eelatiny.<\/p>\n<p>Jin\u00fd sc\u00e9n\u00e1\u0159 reakce nast\u00e1v\u00e1 v d\u016fsledku esterifikace a transesterifikace l\u00e9\u010diva, kter\u00e9 obsahuje jako prvek polyoly.<\/p>\n<p>Dobrou zpr\u00e1vou je, \u017ee tuto reakci m\u016f\u017eete tak\u00e9 omezit.<\/p>\n<p>Jak?<\/p>\n<p>Pravideln\u011b pou\u017e\u00edvejte sko\u0159\u00e1pkovou formulaci bez glycerolu; je to proto, \u017ee glycerol je vysoce reaktivn\u00ed ve srovn\u00e1n\u00ed s jin\u00fdmi polyoly.<\/p>\n<p>Pokud ne, m\u016f\u017eete do matrice v\u00fdpln\u011b p\u0159idat spr\u00e1vn\u00e9 mno\u017estv\u00ed polyvinylpyrrolidonu.<\/p>\n<p>V\u0161imn\u011bte si, \u017ee chemick\u00e1 reakce nen\u00ed omezena pouze na tyto dva sc\u00e9n\u00e1\u0159e; mohou se li\u0161it v z\u00e1vislosti na chemick\u00fdch prvc\u00edch m\u011bkk\u00e9ho gelu.<\/p>\n<p>V\u017edy, kdy\u017e si nejste jisti \u0159e\u0161en\u00edm, mus\u00edte se v\u017edy poradit s renomovan\u00fdm v\u00fdrobcem.<\/p>\n<h3><em>\u00b7 Fyzik\u00e1ln\u00ed interakce ve formulaci m\u011bkk\u00fdch gelov\u00fdch kapsl\u00ed<\/em><\/h3>\n<p>V z\u00e1sad\u011b k fyzik\u00e1ln\u00ed interakci v m\u011bkk\u00e9m gelu doch\u00e1z\u00ed v d\u016fsledku neust\u00e1l\u00e9ho pohybu prvk\u016f v\u00fdpln\u011b jako celku ve sko\u0159\u00e1pce.<\/p>\n<p>Stejn\u011b tak by akce mohla b\u00fdt p\u0159es vn\u011bj\u0161\u00ed kryt.<\/p>\n<p>P\u0159esto se m\u016f\u017ee vyskytovat prost\u0159ednictv\u00edm pl\u00e1\u0161t\u011b nebo v matrici v\u00fdpln\u011b.<\/p>\n<p>Nyn\u00ed stupe\u0148 fyzik\u00e1ln\u00edch interakc\u00ed vn\u011bj\u0161\u00edho pl\u00e1\u0161t\u011b a v\u00fdpln\u011b nakonec z\u00e1vis\u00ed na dvou faktorech.<\/p>\n<p>Zahrnuj\u00ed typ a vhodnost chemick\u00e9ho slo\u017een\u00ed vn\u011bj\u0161\u00edho krytu i v\u00fdpln\u011b.<\/p>\n<p>Dal\u0161\u00edm z\u00e1kladn\u00edm faktorem je nav\u00edc mno\u017estv\u00ed specifick\u00fdch slo\u017eek.<\/p>\n<p>Typick\u00fdm p\u0159\u00edkladem je mno\u017estv\u00ed vody.<\/p>\n<p>V\u017edy udr\u017eujte obsah vody v n\u00e1plni na kritick\u00e9 hodnot\u011b nep\u0159esahuj\u00edc\u00ed p\u0159ibli\u017en\u011b 5 %.<\/p>\n<p>Tady to m\u00e1\u0161. Pamatujte, \u017ee m\u00edra \u00fasp\u011bchu va\u0161eho v\u00fdrobn\u00edho procesu je p\u0159\u00edmo \u00fam\u011brn\u00e1 jeho schopnosti minimalizovat tyto interakce.<\/p>\n<p>Krom\u011b technik si mus\u00edte b\u00fdt v\u011bdomi vybaven\u00ed.<\/p>\n<p>Na\u0161e dal\u0161\u00ed sekce se zam\u011b\u0159\u00ed na formula\u010dn\u00ed za\u0159\u00edzen\u00ed.<\/p>\n<p>Dr\u017e se m\u011b.<\/p>\n<h2>Za\u0159\u00edzen\u00ed pro p\u0159\u00edpravu m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed<\/h2>\n<p>Pro prov\u00e1d\u011bn\u00ed procesu formulace jsou dostupn\u00e9 r\u016fzn\u00e9 zp\u016fsoby. N\u011bkter\u00e9 z nich zahrnuj\u00ed:<\/p>\n<ul>\n<li>Proces rota\u010dn\u00ed matrice<\/li>\n<li>Proces pokovov\u00e1n\u00ed<\/li>\n<li>Recipro\u010dn\u00ed lisovac\u00ed proces<\/li>\n<li>Alcogelov\u00fd proces<\/li>\n<li>Beze\u0161v\u00e9 \u017eelatinov\u00e9 kapsle.<\/li>\n<\/ul>\n<p>P\u0159esto se budeme dr\u017eet procesu Rota\u010dn\u00ed matrice.<\/p>\n<p>Postup prob\u00edh\u00e1 v rota\u010dn\u00edm lisovac\u00edm za\u0159\u00edzen\u00ed.<\/p>\n<p><a href=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-10-Soft-gelatin-encapsulation-machine.jpg\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-10-Soft-gelatin-encapsulation-machine.jpg\" class=\"aligncenter size-full wp-image-7139 lazyload\" alt=\"Stroj na zapouzd\u0159en\u00ed m\u011bkk\u00e9 \u017eelatiny\" width=\"568\" height=\"340\"><noscript><img decoding=\"async\" class=\"aligncenter size-full wp-image-7139\" src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-10-Soft-gelatin-encapsulation-machine.jpg\" alt=\"Stroj na zapouzd\u0159en\u00ed m\u011bkk\u00e9 \u017eelatiny\" width=\"568\" height=\"340\" srcset=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-10-Soft-gelatin-encapsulation-machine.jpg 568w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-10-Soft-gelatin-encapsulation-machine-300x180.jpg 300w\" sizes=\"(max-width: 568px) 100vw, 568px\" \/><\/noscript><\/a><\/p>\n<p style=\"text-align: center;\"><em>Stroj na zapouzd\u0159en\u00ed m\u011bkk\u00fdch kapsl\u00ed<\/em><\/p>\n<p>A mimochodem, v p\u0159\u00edpad\u011b, \u017ee pot\u0159ebujete tento stroj a dal\u0161\u00ed souvisej\u00edc\u00ed p\u0159\u00edslu\u0161enstv\u00ed, m\u016f\u017eete zkontrolovat toto: <a href=\"https:\/\/www.saintytec.com\/softgel-encapsulation-machine\/\">Stroj a za\u0159\u00edzen\u00ed na zapouzd\u0159en\u00ed m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed<\/a>.<\/p>\n<p>Dovolte mi, abych v\u00e1s provedl pracovn\u00edm mechanismem rota\u010dn\u00ed matrice.<\/p>\n<p><strong>i.<\/strong> Zav\u00e1d\u011bjte dva \u017eelatinov\u00e9 prou\u017eky nep\u0159etr\u017eit\u011b do sestavy rotuj\u00edc\u00ed matrice.<\/p>\n<p><strong>ii.<\/strong> Rota\u010dn\u00ed matrice pak formuje dva p\u00e1sy na dv\u011b poloviny pro kompletn\u00ed kapsli.<\/p>\n<p><strong>iii.<\/strong> Pot\u00e9 se p\u00e1sky nyn\u00ed sb\u00edhaj\u00ed vedle plnic\u00edho injektoru.<\/p>\n<p><strong>iv.<\/strong> Plnic\u00ed injektor p\u0159esn\u011b m\u011b\u0159\u00ed a zav\u00e1d\u00ed po\u017eadovan\u00fd objem plnic\u00ed matrice do kapsl\u00ed. Tryska m\u00e1 \u010derpadlo, kter\u00e9 iniciuje tok materi\u00e1lu.<\/p>\n<p><strong>proti.<\/strong> Pot\u00e9 kladkov\u00fd syst\u00e9m p\u0159enese pln\u00e9 kapsle do t\u011bsnic\u00ed komory. B\u011bhem tohoto procesu se sestava matrice ot\u00e1\u010d\u00ed.<\/p>\n<p>V\u00fd\u0161e uveden\u00fd proces je kompletn\u00ed proces pro zapouzd\u0159en\u00ed.<\/p>\n<p>Pozn\u00e1mka:<\/p>\n<p>B\u011bhem v\u00fd\u0161e uveden\u00e9ho procesu je t\u0159eba regulovat n\u00e1sleduj\u00edc\u00ed parametry: teplotu \u017eelatiny a n\u00e1pln\u011b, tlou\u0161\u0165ku p\u00e1sky, \u0161\u00ed\u0159ku t\u011bsn\u011bn\u00ed, mno\u017estv\u00ed n\u00e1pln\u011b.<\/p>\n<p><strong>vi.<\/strong> Pot\u00e9 n\u00e1sleduje su\u0161en\u00ed. P\u0159eneste kapsle do tunelu pro su\u0161en\u00ed v bubnov\u00e9 su\u0161i\u010dce. Tato sekce m\u00e1 optim\u00e1ln\u00ed teplotu a stla\u010den\u00fd vzduch.<\/p>\n<p><strong>vii.<\/strong> Jakmile jsou kapsle dostate\u010dn\u011b such\u00e9, p\u0159esu\u0148te je do m\u00edstnosti s n\u00edzkou vlhkost\u00ed pro dal\u0161\u00ed cyklus su\u0161en\u00ed.<\/p>\n<p>B\u011bhem su\u0161en\u00ed je nezbytn\u00e9 sledovat n\u00e1sleduj\u00edc\u00ed parametry: vlhkost \u017eelatiny, vlhkost n\u00e1pln\u011b a tvrdost kapsle.<\/p>\n<p>Hlavn\u00edm c\u00edlem su\u0161en\u00ed je zajistit dosa\u017een\u00ed vlhkosti \u017eelatinov\u00e9 sko\u0159\u00e1pky cca 6 \u2013 8%.<\/p>\n<p>Proces se v tomto bod\u011b nezastav\u00ed.<\/p>\n<p>Ur\u010dit\u011b mus\u00edte zaru\u010dit vhodnost m\u011bkk\u00fdch gelov\u00fdch kapsl\u00ed.<\/p>\n<p>Kone\u010dn\u00fd postup zahrnuje n\u011bkolik dokon\u010dovac\u00edch opat\u0159en\u00ed prov\u00e1d\u011bn\u00fdch na v\u00fdrobc\u00edch.<\/p>\n<p><strong>viii.<\/strong> Vyberte m\u011bkk\u00e9 gely a rozt\u0159i\u010fte je podle velikost\u00ed.<\/p>\n<p><strong>ix.<\/strong> Zkontrolujte produkty a odstra\u0148te po\u0161kozen\u00e9.<\/p>\n<p><strong>x.<\/strong> Nyn\u00ed m\u016f\u017eete m\u011bkk\u00e9 gelov\u00e9 kapsle vyle\u0161tit a vy\u010distit, abyste odstranili ne\u017e\u00e1douc\u00ed materi\u00e1ly na povrchu kapsl\u00ed, jako je glycerin nebo olej.<\/p>\n<p><strong>xi.<\/strong> Nakonec m\u011bkk\u00e9 gely zabalte do optim\u00e1ln\u00edch podm\u00ednek, tj. rozsah teplot 20 \u2013 28\u00b0C. Relativn\u00ed vlhkost by m\u011bla b\u00fdt asi 40 %. Tyto podm\u00ednky zlep\u0161uj\u00ed stabilitu m\u011bkk\u00fdch gel\u016f.<\/p>\n<p>Stru\u010dn\u011b \u0159e\u010deno, proces formulace m\u011bkk\u00e9ho gelu se scvrk\u00e1v\u00e1 na \u0159adu krok\u016f.<\/p>\n<p><strong>i.<\/strong> P\u0159\u00edprava \u017eelatiny<\/p>\n<p><strong>ii.<\/strong> P\u0159\u00edprava v\u00fdpl\u0148ov\u00e9ho materi\u00e1lu<\/p>\n<p><strong>iii.<\/strong> Zapouzd\u0159en\u00ed<\/p>\n<p><strong>iv.<\/strong> Su\u0161en\u00ed<\/p>\n<p><strong>proti.<\/strong> Inspekce<\/p>\n<p><strong>vi.<\/strong> Le\u0161t\u011bn\u00ed<\/p>\n<p><strong>vii.<\/strong> Obal<\/p>\n<p>Poj\u010fme k dal\u0161\u00edmu aspektu diskuse.<\/p>\n<h2>Klasifikace m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed<\/h2>\n<p>M\u011bkk\u00e9 gely m\u016f\u017eeme seskupit do dvou \u0161irok\u00fdch kategori\u00ed, tzn.<\/p>\n<ul>\n<li>Typ A<\/li>\n<li>Typ B<\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-11-Different-sizes-of-soft-gelatin-capsules.jpg\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-11-Different-sizes-of-soft-gelatin-capsules.jpg\" class=\"aligncenter size-full wp-image-7140 lazyload\" alt=\"R\u016fzn\u00e9 velikosti m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed\" width=\"911\" height=\"431\"><noscript><img decoding=\"async\" class=\"aligncenter size-full wp-image-7140\" src=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-11-Different-sizes-of-soft-gelatin-capsules.jpg\" alt=\"R\u016fzn\u00e9 velikosti m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed\" width=\"911\" height=\"431\" srcset=\"https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-11-Different-sizes-of-soft-gelatin-capsules.jpg 911w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-11-Different-sizes-of-soft-gelatin-capsules-300x142.jpg 300w, https:\/\/www.saintyco.com\/wp-content\/uploads\/2019\/05\/Figure-11-Different-sizes-of-soft-gelatin-capsules-768x363.jpg 768w\" sizes=\"(max-width: 911px) 100vw, 911px\" \/><\/noscript><\/a><\/p>\n<p style=\"text-align: center;\"><em>\u00a0R\u016fzn\u00e9 velikosti m\u011bkk\u00fdch \u017eelatinov\u00fdch kapsl\u00ed<\/em><\/p>\n<h3>\u00b7 Typ A<\/h3>\n<p>M\u011bkk\u00e9 gely kategorie A jsou dosa\u017eiteln\u00e9 procesem kysel\u00e9 hydrol\u00fdzy na prekurzoru isoelektrick\u00e9ho bodu Ph-9.<\/p>\n<p>Prim\u00e1rn\u00edm zdrojem tohoto m\u011bkk\u00e9ho gelu je vep\u0159ov\u00e1 k\u016f\u017ee.<\/p>\n<h3>\u00b7 Typ B<\/h3>\n<p>Na rozd\u00edl od typu A m\u016f\u017eete typ B vyrobit z alkalick\u00e9 hydrol\u00fdzy na prekurzoru, kter\u00fd vykazuje izoelektrick\u00fd bod p\u0159i Ph-4,7.<\/p>\n<p>Zv\u00ed\u0159ec\u00ed kosti jsou vynikaj\u00edc\u00edm zdrojem pro v\u00fdrobu tohoto druhu m\u011bkk\u00e9ho gelu.<\/p>\n<h2>Z\u00e1v\u011br<\/h2>\n<p>Te\u010f to v\u0161echno m\u00e1\u0161.<\/p>\n<p>Jsem si jist\u00fd, \u017ee jste se hodn\u011b nau\u010dili o slo\u017een\u00ed m\u011bkk\u00fdch gelov\u00fdch tobolek.<\/p>\n<p>Je z\u0159ejm\u00e9, \u017ee se zvy\u0161uj\u00edc\u00ed se popt\u00e1vkou po m\u011bkk\u00e9m gelu ji\u017e do\u0161lo k mnoha pokrok\u016fm v optimalizaci biologick\u00e9ho v\u00fdkonu kapsl\u00ed.<\/p>\n<p>Nyn\u00ed p\u0159edev\u0161\u00edm rozum\u00edte procesu formulace.<\/p>","protected":false},"excerpt":{"rendered":"<p>You cannot invest in the Softgel industry without proper knowledge on soft gelatin capsule formulation. It doesn\u2019t matter whether you want to invest in the CBD oil Softgel, food supplement Softgel or medicine Softgel. You must know exactly what soft gelatin capsules are made of. Consequently, in this piece, we shall discuss several issues about [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7128","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Soft Gelatin Capsule Formulation - SaintyCo<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.saintyco.com\/cs\/formulace-mekkych-zelatinovych-kapsli\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Soft Gelatin Capsule Formulation - SaintyCo\" \/>\n<meta property=\"og:description\" content=\"You cannot invest in the Softgel industry without proper knowledge on soft gelatin capsule formulation. 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